Protection against the photosensitized skin irritancy of chlorpromazine by cyclodextrin complexation.
نویسندگان
چکیده
منابع مشابه
Skin protection for photosensitized patients.
BACKGROUND AND OBJECTIVE The goal of this study was to evaluate various creams for their capability to protect photosensitized skin from visible light. STUDY DESIGN/MATERIALS AND METHODS Two cover creams and creams containing various combinations of Vaseline with TiO(2), ZnO, and Fe(2)O(3) were used to measure the reduced light transmission and the light absorption spectrum. In vitro and in v...
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Orally administrated diosgenin, a steroidal saponin found in several plants including Dioscorea villosa, recovers skin thickness reduced in ovariectomized mice, and plays an important role in the treatment of hyperlipidemia. Thus, diosgenin is an active element of cosmeceutical and dietary supplements. However, we have already elucidated that the skin distribution and absolute oral bioavailabil...
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Hand disinfection with short-chain aliphatic alcohols, so-called "rub-ins" is the method of choice for cross-infection prevention in health care environments, but their irritant potential is not well known. Skin tolerance is a major compliance factor, and a high proportion of health care workers suffer from low-grade irritant contact dermatitis. Therefore, assessment of the irritancy of the ski...
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This study was conducted to investigate whether agmatine (AGM) provides protection against oxidative stress induced by treatment with chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive oxygen species and efficiency of antioxidant protection in the brain homogenates of forebrain cortexes prepared 48 h after treatment were investigated. Chlorpromazine was applied intraperitone...
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We report temperature-dependent acoustic and densimetric data on changes in volume, expansibility, and adiabatic compressibility accompanying the binding of 1-adamantanecarboxylic acid (AD) to beta-cyclodextrin (beta-CD). We interpret our volumetric results in terms of hydration. Based on our compressibility and expansibility data, we estimate that, at 25 degrees C, the binding of AD to beta-CD...
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ژورنال
عنوان ژورنال: Journal of Pharmacobio-Dynamics
سال: 1985
ISSN: 0386-846X,1881-1353
DOI: 10.1248/bpb1978.8.788